Drugs for Mycoplasmosis

Antimycoplasmal Drugs

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Antimycoplasmal

Antimycoplasmal drugs defined as drugs that acts on mycoplasmal species that causing several diseases in poultry. Mycoplasmal is a unique organism which have an absent cell wall. That’s why all antibiotics do not act on mycoplasma spp except pleuromutilins & macrolides.

There are several types of antimicrobial groups specifically suppress the mycoplasma spp but never kill this bacteria due to intracellular location.

Classification

It is classified in this way-

Pleuromutilins

Tiamulin (C32H51NO8S) defined as antimycoplasmal semi synthetics drugs derived from diterpene antimicrobials with a pleuromutilin chemical structure. Tiamulin hydrogen fumarate is the form of Tiamulin which is previously known as Tiamutin. Pleuromutilins is semi synthetic compounds that discover 1950.

Sulphonamide

The sulfonamides are derivatives of p-aminobenzene sulfonic acid and are structurally similar to p-aminobenzoic acid (PABA), an intermediate in bacterial synthesis of folic acid. They behave as weak organic acids that are poorly water soluble unless prepared as sodium salts. Concentrated solutions of the sodium

salts of most sulfonamides are very alkaline and may be corrosive. The solubility of a sulfonamide is not influenced by the presence of other sulfonamides in the solution.

Ref Handbook of veterinary pharmacology

This is termed the law of independent solubility and is the primary reason for the use of sulfonamide mixtures in order to increase the combined total sulfonamide concentration to prevent renal precipitation and thus reduce toxicity.

others chlortetracycline, macrolide, aminoglycoside, Fluoroquinolone

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