Treatment Of Avian Influenza
Treatment of Avian Influenza is very difficult task ever in the field industry. But, all types of Avian Influenza are controllable except H5 type. Avian Influenza is an infectious disease, which is caused by influenza type A virus, which ranges from mild or even asymptomatic to an acute, fatal form, which is originated from the family of orthomyxoviridae.
In other words, it also called “Bird Flu” or “Fowl Plaque”. Treatment of this disease totally depends on the type of infection and geographic location, which takes a strict control mechanism, which we can not elucidate in this topic.
there is a two-type infection, which is caused by the Avian Influenza virus in the poultry population, in which one-type actually treatment, while the other one-type not possible due to severe mortality.
Therefore, we are appending the treatment separately-
High Pathogenic Avian Influenza ( H5N1)
there are several types of drugs, which are available for treating HPAI infection, but there are lots of limitations in the case of birds. these are-
a) Amantadine Hydrochloride:
the exact mode of action is still clearly unknown, but it is generally hampering the producing of viral nucleic acid into the host by obstructing the operation of the transmembrane domain of the viral M2 protein.
It has been registered for use in humans treating Influenza type A virus since 1966, But, it is just reducing the severity of the infection of Influenza type A virus, while never cure the disease completely.
in the labrotory examination, the drug was found to reduce losses in poultry, but initial benefit was negated by emergences of drug resistancevirus, hence it is not advised for the treating in poultry.
the writer has tried this drug during the outbreak of HPAI in the broiler, where was mortality reached 50 birds/hours, @ 5mg/kg body weight in 48 hours drinking water.
but, unfortunately, the case was never cured ultimately culled the flocks. But, the finding is initially carried out due to severe virulency of Avian influenza virus assuage develope resistance in this drug.
It is the broad spectrum anti-influenzal drug, that effective in all types of Neuraminidase (NA) protein a viral surface enzyme.
which is responsible for the replication and deactivate of influenza viruses A and B, by preventing the release of viruses from infected host cells. but the application of this drug is documented yet the poultry.
Prophylaxis treatment of Avian Influenza infection in poultry is being treated by Oseltamivir successfully result-oriented in the field @1mg/kg body weight. In the year 2018.
HPAI was breaking out throughout Bangladesh, but this drug practically applies in some egg-laying farms, fortunately, the symptoms were totally denied, where apply this drug prophylactically.
But, In the case of the egg layer hen, when birds are affected, & showing hemorrhagic peritonitis caused by HPAI, not treatment is successful, So it is a wise decision to culled the birds immediately.
Low Pathogenic Avian Influenza (LPAI)
It is less devastating compared to mortality between HPAI. It is being effectively controlled without the application of Anti-Influenzeal drugs in the field.
The success of the treatment depends on the complication of the clinical sign, postmortem findings,& diagnosis of disease. If you unaware, please visit the links:
It is required at least two weeks to fully recover to its previous state, and birds became off feed at least one week at the final stage.
But in this period, severe viral replication occurred especially in the egg-follicle, which is why drop off egg production for a long time due to the destruction of egg follicle or inability to produce ovum in the reproductive tract in the poultry.
Some poultry consultant suggests disinfectant with paracetamol in drinking water but avoids antibiotics due to resistance by the virus at least seven days in case of broiler.
In the case of the egg layer, the birds are placed in the cage, Treatment continues as per broiler but floor rearing system iodine-based disinfectants with antimycoplasmal drugs successful.Follow Us