Ceftriaxone In Poultry
Ceftriaxone in poultry is an antibiotic, a semisynthetic cephalosporin of the third generation. It is bactericidal against a wide range of Gram-negative bacteria but limited active on Gram-positive and by inhibiting the mucopeptide synthesis in the bacterial cell wall in poultry.
General characteristics
- the substance penetrates into almost all body tissues, including the cerebrospinal fluid by the parenteral administration
- It disseminates primarily into extracellular water, showing bind to binding to albumin and in normal adults,
- for treating a wide spectrum of pathogens ceftriaxone should be combined with an appropriate antimicrobial agent with additional anaerobic coverage
- its longer duration of action (half-life -t½ 8 hr), permitting once, or at the most twice-daily dosing.
- Penetration into CSF is good and
- elimination occurs equally in urine and bile.
Mechanism of action
Ceftriaxone act as a bactericidal activity that results from the inhibition of bacterial cell wall synthesis.
It has a high degree of stability in the presence of lactamases produced by Gram-negative
and Gram-positive bacteria.
It showing synergistic effects of ceftriaxone and aminoglycosides on certain Gram-negative bacteria that have been noted in vitro.
Minimum inhibitory concentration (MIC)
according to a human study, minimum inhibitory concentrations for 90% of organisms (MIC90s) of ceftriaxone for most organisms is extremely low when compared with attainable serum concentrations-
- Salmonella spp- 0.06 to 0.5g/ml
- Escherichia coli– (MIC90 = 0.1 µg/ml),
- Klebsiella species- (MIC90 = 0.1 µg/ml),
- Proteus species- (MIC90 = 0.2 µg/ml),
- Enterobacter species- (MIC90 = 0.3 µg/ml),
- Serratia species- (MIC90 = 0.4 µg/ml),
- Streptococcus agalactiae- (MIC90 = 0.06 µg/ml)
- Staphylococcus aureus (β-lactamase producers) (MIC90 = 2 µg/ml)
Microbiology
It has a great microbial sprectrum especially gram negative bacteria. Poultry population is more vulnerable to gram negative bacterial infection which cause by the wide range bacteria family.Commonly Gram positive aerobes susceptible species
- Streptococcus pyogenes*
- Streptococcus pneumoniae
- Staphylococcus aureus
- Streptococcus agalactiae
- Streptococcus bovis
Gram-positive anaerobes
Peptococcus niger
Peptostreptococcus spp.
Gram-negative aerobes
- Salmonella gallinerium
- Salmonella pullorum
- Pasturella multicida
- Mycoplasma gallisepticaum
- Citrobacter koseri1
- Escherichia coli*1
- Haemophilus influenzae*
- Haemophilus parainfluenzae*
- Klebsiella pneumoniae* 1
- Klebsiella oxytoca* 1
- Moraxella catarrhalis*
- Morganella morganii1
- Neisseria meningitidis*
- Proteus mirabilis*1
- Proteus vulgaris1
- Providencia spp.1
- Salmonella spp.1
- Serratia spp.1
- Shigella spp
Gram-positive aerobes
- Staphylococcus epidermidis*$ (MSSE)
Gram-negative aerobes
- Citrobacter freundii 1
- Enterobacter spp. 1,3
- Pseudomonas aeruginosa $ 2
- Inherently resistant species
Gram-positive aerobes
- Enterococcus faecalis
- Enterococcus faecium
- Listeria monocytogenes
- Staphylococcus aureus MRSA
- Staphylococcus epidermidis MRSE
Gram-positive anaerobes
Clostridium difficile
Gram-negative aerobes
- Acinetobacter spp.
- Achromobacter spp.
- Aeromonas spp.
- Alcaligenes spp.
- Flavobacterium spp.
- Legionella gormanii
Gram-negative anaerobes
Bacteroides spp.
Others
- Chlamydia spp.
- Chlamydophila spp.
- Mycobacterium spp.
- Mycoplasma spp.
- Rickettsia spp.
- Ureaplasma urealyticum
Indication
- Para-typhoid infection
- Non-Specific airsaculitis
- Gram-Negative bacterial infection associated with Newcastle disease, infectious bronchitis, acute Mycoplasmosis, Low pathogenic Avian influenza infection
Dosages
- For the pullorum diseases which only occurred at the early stages of chicks, ceftriaxone is given at 0.5-1mg/gram body weight. Broadly, 5-10 mg/kg enough to control pullorum disease intramuscularly in poultry.
- For the fowl typhoid and cholera, which is affected mainly in adult birds, it gives at 10-50mg/kg body weight according to the number of mortality.
I have been practicing up to 60mg/kg body weight where mortality reach to 80-90 birds/day in both cases called fowl typhoid and fowl cholera.
Ramzan, DVM, poultry Veterinarian
Author observation
There is no exact information about the application of the ceftriaxone on books and the internet. I have been practicing poultry medicine in my area where all types of poultry diseases are more prevalence all year round. In 2016, I have been applied ceftriaxone on fowl typhoid and got tremendous results.
but I have struggled to apply it due to the dose of ceftriaxone not mention in veterinary pharmacology books in the field of poultry. Therefore, I used my third sense and dosing started from 10 mg/kg body weight.
At present, it has been using all over Bangladesh according to the dose I have already mentioned. Since then. I have been trying to use all types of gram-negative bacteria and getting a satisfying result on every gram-negative bacterial infection. It is time to include the details of ceftriaxone in veterinary pharmacology books. By which lots of veterinary students and professionals enhance their skills and knowledge.
Incompatibilities
It is not compatible with calcium-containing solutions such as Hartmann’s solution and Ringer’s solution.
According to literature reports, ceftriaxone is not compatible with amsacrine, vancomycin, fluconazole,
aminoglycosides, and labetalol.
Shelf life
- Unopened: 2 years.
- Opened & after reconstitution:
Chemical and physical in-use stability has been showing for 24 hours at 2 o C to 8oC.
From microbiological findings, the product should be used immediately. If not used immediately, the unused storage times and conditions prior to use are the responsibility of the user and would not be longer than 24 hours at 2-9 C, otherwise, any unused portion must be discarded.
User Manual
- Ceftriaxone .5-2gram powder for solution for injection or infusion should be dissolved in 3.5 ml of 1 % w/v lidocaine hydrochloride injection solution.
- Ceftriaxone should not be mixed in the same syringe with any medicinal product other than 1% w/lidocaine hydrochloride solution (for intramuscular injection only).
- The reconstituted solution should be shaken up to 60 seconds to ensure complete dissolution of ceftriaxone. When reconstructing for intramuscular or intravenous injection, the white to yellowish crystalline powder gives a pale yellow to the amber solution.
Ramzan, DVM, Poultry Veterinarian
Related Post
References
A Textbook of Clinical Pharmacology and Therapeutics 5th-edition
ceftriaxone-tyrol-pharma-article-29-referral-annex-i-ii-iii_en
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