Lasalocid is a not only carboxylic divalent polyether ionophore but also antibacterial & coccidiostst that is a mold fermentation product of Streptomyces lasaliensis . Its commonly used as a feed additives named lasalocid sodium (C34H53Nao8) in poultry worldwide.
Mode of action
Lasalocid Ionophores upset the osmotic balance of the protozoan cell by altering the permeability of cell membranes for alkaline metal cations. It also transport big cation called dopamine.
Endogenous stages affected of Emeria spp
Lasalocid sodium Ionophores act on against extracellular sporozoites, early tropozoite and merozoites.
Its acts as a broad spectrum antibacterial & coccidiostsat in poultry. It has a selective antibacterial activity in gram positive bacteria but Enteriobacteriace may naturally resistant. But it is many used coccidiostat in poultry.
Lasalocid Ionophores aborbed orally but absorption is slower in from intestine in poultry. It is rapidly & extensively metabolized in liver & metabolites excreted through faces & bile.
75-125g (0.0075–0.0125%)/ton medicated feed for prophylaxis of coccidiosis in poultry.
Lasalocid sodium will stimulate water consumption and excretion resulting in a wet litter. With slight overdoses, it may cause depress weight gain in poultry.
For meat & eggs 3 days.
Do you know which types of coccidia or Emeria spp kill by polyether ionophores?
Extra cellular stages of coccidia or Emeria species can only susceptable by Polyether Ionophores in poultry.