Maduramicin amonium is a monovalent monoglycoside polyether ionophore which consist of 90% ammonium salt that is a fermentation product of Actinomadura yumaense.
It can be grade as two types Alpha meduramycin & beta maduramycin from its definition.
Alpha meduramycin defined as that consisting 90% ammonium salt of a polyether monocaboxylic ionophore with -OH3 at the C5 of the ring
Beta maduramycin define as that consisting ammonium salt of a polyether monocaboxylic ionophore with –OH group at C5 of the ring.
Maduramicin (alpha & beta) does not adversely affect egg production or egg quality. Its causes adverse effect on growth and feathering may occur at higher doses >6mg/kg (≥6 ppm).
Mode of Action
Maduramycin sodium interfering with transport of K+ & Na+ ions through cell membrane → influx of positively charged ions (H+) → upset of osmotic balance Causing disturbances mitochondrial function of intracellular coccidian (Selective E. spp.)
Endogenous at sages affect of Emeria species
It induces anticoccidial effect on asexuall stages sporozoite, tropozoite & merozoite of selective Emeria spp of poultry.
It used as a coccidiostat for prevention & control of coccidiosis thereby increased feed efficiency, improved weight gain, reduced number of gut lesion & mortality in poultry. It is moderately active against in gram positive bacteria.
Maduramycin ionophores are metabolized in the liver, and are excreted mostly into bile and feces as parent compound and metabolites in all species. Its rapidly eliminated form body two third metabolites excreated within 2 days & total 90-95% excreated within seven days that shows on animal study.
Meduramycin is effective for the prevention of coccidiosis @ 5mg/kg body weight. But in higher dosages e.g 15 mg/kg body weight may cause significant weight gain depression & 8-14 mg/kg cause reduced feed efficiency in poultry. It may causes fatal toxicity in oral dosages.
For the control & prevention of coccidiosis it may use in replacement pullets up to 16 week of age; turkey poults up to 12 week of age.
Maduramycin not a teratogenic, Foetotoxic, carcinogenic in animal study. It may incompatible with Tiamulin at higher dosage above >15-20 mg/kg body weight.
It is use only for the prevention of coccidiosis in broiler only not use in laying birds. It does to mix with others ionophopres that causing mixing error & Ionic imbalance. It does not provide horse or others equine species which causing fatal toxicosis or somehow happened mortalty.
For egg & meat 5 days. It is suggested that maduramicin is acceptable without risk for use in the poultry feed @ 5mg/kg body weight for the prevention & control of coccidiosis & fattening poultry subject to mention withdrawal period.
Maduramycin should be stored under 15 degree Celsius. Protect from direct sunlight which became cause decreased activity of maduramycin.
Available for form
It’s available as 1% & 5% as feed coccidiostat in the market.
Maduramycin show graeter anticoccidial activity is due to disorder in ion metabolism (potassium and sodium in particular).