Polyether Ionophores In Poultry

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Polyether Ionophores

Its define as natural & biologically  active compound/ substances produced by fermentation of streptomyces or actinomadura. Its destroy Emeria spp by inferring balance od most important ion specially sodium & potassium. There are somes drugs included this class. Its also called coccidiostat in earlier time. Its only used via poultry for controlling coccidiosis in poultry.

The polyether ionophore antibiotics were first discovered in the early 1950s, and their anticoccidial activities were recognized in the late 1960s. Because of their broad spectrum of activity and the development of drug resistance to other agents, the ionophores gained widespread usage in the poultry industry soon after their introduction. Most commenly used polyether ionophores generic name given below

Classification

Polyether Ionophores classified by two class

a) Monovalent ionophores

Its define as Polyether Ionophoes that have valency one called Monovalent ionophores. eg monensin, narasin and salinomycin & Monovalent glycosidic ionophores (maduramicin and semduramycin)

Monensin

Salinomycin

Narasin

Maduramycin

Samduaramycin

b) Divalent ionophores 

Its define Polyether as Ionophoes that have valency two called Divalent ionophores

for example Lasalosid

FDA approval

Polyether Ionophores

Monensin

Lasalosid

Salinomycin

Narasin

Maduramycin

Samduaramycin

FDA approval

1971

1976

1983

1988

1989

1995

Approved Dosages

Polyether Ionophores

Monensin

Lasalosid

Salinomycin

Narasin

Maduramycin

Samduaramycin

Approved Dosages

0.01–0.0121 %

0.0075–0.0125%

0.004–0.0066%

54–72g/T

5–6 ppm

25ppm

In here % means drugs 100 gm feed , PPM means Parts per million

Withdrawal  period

Polyether Ionophores

Monensin

Lasalosid

Salinomycin

Narasin

Maduramycin

Samduaramycin

Withdrawal  period (Days)

00

03

00

00

05

00

Adverse Effect

Polyether sodium (Na+)  ionophores Increased intracellular Na+ concentrations will damage mitochondria and Golgi body into host.

Intracellular Na+ further exchanges for extracellular  Ca2+ (calcium Ion), thereby increasing intracellular Ca2+ concentrations ([Ca2+].

this higher calcium ion in cardiac & skeletal muscle responsible for induce main toxicity of these drugs. Its also increase catecholamine secretion of chromaffin cells caused jeopardize the cardiac arrhythmia. It increase various hormone secretions in endocrine cells .

Related Post

Coccidiosis | Types Of Anticoccidial Drugs

Coccidiosis | Characteristics of Anticoccidial Drugs

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