Toltrazuril is a synthetic broad spectrum anticoccidial & antiproptozoal properties under the class of Triazinenitrione derivatives used for coccidiosis in poultry. Totrazuril is a water soluble drugs that used in poultry & others species. Sometimes which dilution may precipeted dilution which more concentrated the 1:1000 (1 ml toltrazuril 2.5% to 1ml drinking water) may result in precipitation.
Mode of Action: Toltrazuril inhibite nuclear division & microchondril activity. Totrazuril damages the wall forming bodies of microgametes & causes severe vascuolisation by inflation of the endoplasmic reticulum in all intracellular development stages of Emeria spp.
Pharmacologic action: Toltrazuril coccidioccidal,potent & active against developing first & second generation schizont & gametes of progenic Emeria spp in various birds like turkey, geese, ducks & others intracellurly & extracellularly.Toltrazuril exhibits long resudial acticity & may protect pultry from 2 weeks.
Indication: Toltrazuril used for control & treatment of coccidiosis in various species of poultry.Toltrazuril may be medicated intermittently instead of conventional continous medication in poultry.
Dosages: 7-100 mg/kg may well tolerable in poultry. 7mg/kg given for 2 consecutive days enough to killed all stages of Emeria in poultry.
Absorption: Toltrazuril is slowly but entensively absorbed the intestine of poultry. Peak plasma concentration is attained within 120 hours. Totrazuril is absorbed 50% or more in poultry.
Metabolism: Toltrazuril is degraded in Toltrazuril sulfone which is persistant & mobile in groundwater.
Distribution: Toltrazuril is attained high concentration in liver, muscles & fats in poultry.
Plasma half life: 196 hours in poultry.
Resudial limit: 2mcg/ka ( acceptable daily intake) in poultry.
Withdrawl period: Meat & eggs 19 days in poultry.
Routes of excretion: Urine & faeces in poultry.
Toxicity & adverse effects: Toltrazuril is well tolareted in poultry
Contraindication: known to hypersensivity in poultry.
Precaution: Toltrazuril is not recommendation for the prevention of coccidiosis in broiler due to cause heavy weight loss. Do not use layer birds which reduced eggs production in poultry.
Drug inetereation: There is cross registance between Toltrazuril & diclazuril in poultry.
Formulation: There are two forms 2.5% & 5% are available in the markets which provide via drinking water in poultry.